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KMID : 0545120210310121667
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Journal of Microbiology and Biotechnology
2021 Volume.31 No. 12 p.1667 ~ p.1671
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Thiolactomide: A New Homocysteine Thiolactone Derivative from Streptomyces sp. with Neuroprotective Activity
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Jang Jun-Pil
Kwon Min-Cheol
Nogawa Toshihiko
Takahashi Shunji
Osada Hiroyuki
Ahn Jong-Seog
Ko Sung-Kyun
Jang Jae-Hyuk
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Abstract
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A new homocysteine thiolactone derivative, thiolactomide (1), was isolated along with a known compound, N-acetyl homocysteine thiolactone (2), from a culture extract of soil-derived Streptomyces sp. RK88-1441. The structures of these compounds were elucidated by detailed NMR and MS spectroscopic analyses with literature study. In addition, biological evaluation studies revealed that compounds 1 and 2 both exert neuroprotective activity against 6-hydroxydopamine (6-OHDA)-mediated neurotoxicity by blocking the generation of hydrogen peroxide in neuroblastoma SH-SY5Y cells.
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KEYWORD
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Thiolactomide, Streptomyces sp., N-acetyl homocysteine thiolactone, neuroprotective activity, 6-hydroxydopamine
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